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Disabled homolog 2 is required for migration and invasion of prostate cancer cells
null
《医学前沿(英文)》 2015年 第9卷 第3期 页码 312-321 doi: 10.1007/s11684-015-0401-3
Disabled homolog 2 (DAB2) is frequently deleted or epigenetically silenced in many human cancer cells. Therefore, DAB2 has always been regarded as a tumor suppressor gene. However, the role of DAB2 in tumor progression and metastasis remains unclear. In this study, DAB2 expression was upregulated along with human prostate cancer (PCa) progression. DAB2overexpression or knockdown effects in LNCaP and PC3 cell lines were verified to address the biological functions of DAB2 in PCa progression and metastasis. LNCaP and PC3 cell lines were generated from human PCa cells with low and high metastatic potentials, respectively. The results showed that DAB2 shRNA knockdown can inhibit the migratory and invasive abilities of PC3 cells, as well as the tumorigenicity, whereas DAB2 overexpression enhanced LNCaP cell migration and invasion. Further investigation showed that DAB2 regulated the cell migration associated genes in PC3 cells, and the differential DAB2 expression between LNCaP and PC3 cells was partly regulated by histone 4 acetylation. Therefore, DAB2 may play an important role in PCa progression and metastasis.
Human microbiome and prostate cancer development: current insights into the prevention and treatment
Solmaz Ohadian Moghadam, Seyed Ali Momeni
《医学前沿(英文)》 2021年 第15卷 第1期 页码 11-32 doi: 10.1007/s11684-019-0731-7
关键词: microbiome prostate cancer prevention treatment molecular pathological epidemiology (MPE) biomarker
Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li
《医学前沿(英文)》 2019年 第13卷 第6期 页码 646-657 doi: 10.1007/s11684-018-0643-y
关键词: androgen-independent prostate cancer normal epithelial cell-specific 1/kallikrein 10 sodium/iodide symporter radiation therapy proliferation
Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing
Grant Perry, Fernando Cortezon-Tamarit, Sofia I. Pascu
《化学科学与工程前沿(英文)》 2020年 第14卷 第1期 页码 4-18 doi: 10.1007/s11705-019-1846-8
关键词: biosensing immunosensor PSA prostate cancer fluorescence
Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and
null
《医学前沿(英文)》 2014年 第8卷 第4期 页码 456-463 doi: 10.1007/s11684-014-0353-z
microRNAs (miRNAs) have played a key role in human tumorigenesis, tumor progression, and metastasis. On the one hand, miRNAs are aberrantly expressed in many types of human cancer; on the other hand, miRNAs can function as tumor suppressors or oncogenes that target many cancer-related genes. This study aimed to investigate the effects of miRNA-200c (miR-200c) on the biological behavior and mechanism of proliferation, migration, and invasion in the prostate cancer cell line Du145. In this study, Du145 cells were transfected with miR-200c mimics or negative control miR-NC by using an X-tremeGENE siRNA transfection reagent. The relative expression of miR-200c was measured by RT-PCR. The proliferation, migration, and invasion abilities of Du145 cells were detected by CCK8 assays, migration assays and invasion assays, respectively. The expressions of ZEB1, E-cadherin, and vimentin were observed by western blot. Results showed that DU145 cells exhibited a high expression of miR-200c compared with immortalized normal prostate epithelial cell RWPE-1. Du145 cells were then transfected with miR-200c mimics and displayed lower abilities of proliferation, migration, and invasion than those transfected with the negative control. The protein levels of ZEB1 and vimentin were expressed at a low extent in Du145 cells, which were transfected with miR-200c mimics; by contrast, E-cadherin was highly expressed. Hence, miR-200c could significantly inhibit the proliferation of the prostate cancer cell line Du145; likewise, miR-200c could inhibit migration and invasion by epithelial-mesenchymal transition.
关键词: miR-200c proliferation migration invasion prostate cancer Du145 cell ZEB1
Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes
《医学前沿(英文)》 2023年 第17卷 第2期 页码 231-239 doi: 10.1007/s11684-022-0939-9
关键词: neoadjuvant radiotherapy oligometastatic prostate cancer radical prostatectomy
《机械工程前沿(英文)》 2022年 第17卷 第1期 页码 3-3 doi: 10.1007/s11465-021-0659-x
关键词: ultrasound image guidance prostate percutaneous intervention parallel robot kinematics identification particle swarm optimization informative value
人体前列腺特异性抗原携带含酮基-脱氧壬酮糖酸的N-聚糖 Article
Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
《工程(英文)》 2023年 第26卷 第7期 页码 119-131 doi: 10.1016/j.eng.2023.02.009
Ketodeoxynononic acid (Kdn) is a rather uncommon class of sialic acid in mammals. However, associations have been found between elevated concentrations of free or conjugated Kdn in relation to human cancer progression. Hitherto, there has been a lack of conclusive evidence that Kdn occurs on (specific) human glycoproteins (conjugated Kdn). Here, we report for the first time that Kdn is expressed on prostate-specific antigen (PSA) N-linked glycans derived from human seminal plasma and urine. Interestingly, Kdn was found only in an α2,3-linkage configuration on an antennary galactose, indicating a highly specific biosynthesis. This unusual glycosylation feature was also identified in a urinary PSA cohort in relation to prostate cancer (PCa), although no differences were found between PCa and non-PCa patients. Further research is needed to investigate the occurrence, biosynthesis, biological role, and biomarker potential of both free and conjugated Kdn in humans.
Maximum independent set in planning freight railway transportation
Gainanov Damir N., Mladenovic NENAD, Rasskazova V. A.
《工程管理前沿(英文)》 2018年 第5卷 第4期 页码 499-506 doi: 10.15302/J-FEM-2018031
This work is devoted to the problem of planning of freight railway transportation. We define a special conflict graph on the basis of a set of acceptable train routes. The investigation aims to solve the classical combinatorial optimization problem in relation to the maximum independent set of vertices in undirected graphs. The level representation of the graph and its tree are introduced. With use of these constructions, the lower and upper bounds for the number of vertices in the maximum independent set are obtained.
关键词: independent set algorithm planning of transportation two-sided estimate
Independent cover meshless particle method for complex geotechnical engineering
Jianqiu WU, Yongchang CAI
《结构与土木工程前沿(英文)》 2018年 第12卷 第4期 页码 515-526 doi: 10.1007/s11709-017-0428-4
关键词: meshless method particle method independent cover CTM geotechnical engineering
《医学前沿(英文)》 2021年 第15卷 第6期 页码 942-942 doi: 10.1007/s11684-021-0876-z
金履忠
《中国工程科学》 2005年 第7卷 第7期 页码 1-6
论证了自主开发在政治、军事、经济、安全、科技等方面的重大意义。建议用10~15年的时间,使我国的绝大多数产业具备自主开发和国际竞争能力;分析了实现这个目标是完全可能的。最后提出了应在思想观念、精神状态、法律法规、政策、体制、宣传舆论等方面创造有利于自主开发的环境。
标题 作者 时间 类型 操作
Human microbiome and prostate cancer development: current insights into the prevention and treatment
Solmaz Ohadian Moghadam, Seyed Ali Momeni
期刊论文
NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition
Jiajia Hu, Wenbin Shen, Qian Qu, Xiaochun Fei, Ying Miao, Xinyun Huang, Jiajun Liu, Yingli Wu, Biao Li
期刊论文
Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing
Grant Perry, Fernando Cortezon-Tamarit, Sofia I. Pascu
期刊论文
Effects of miR-200c on the migration and invasion abilities of human prostate cancer Du145 cells and
null
期刊论文
Neoadjuvant radiohormonal therapy for oligo-metastatic prostate cancer: safety and efficacy outcomes
期刊论文
罗军:Treatment Selection in Prostate Cancer(2019年8月16日)
2021年04月22日
会议视频
Ultrasound-guided prostate percutaneous intervention robot system and calibration by informative particle
期刊论文
人体前列腺特异性抗原携带含酮基-脱氧壬酮糖酸的N-聚糖
Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
期刊论文
Maximum independent set in planning freight railway transportation
Gainanov Damir N., Mladenovic NENAD, Rasskazova V. A.
期刊论文
黄教悌:前列腺癌进展和耐药的代谢学机制(2019年8月16日)
2021年04月22日
会议视频
章青:前列腺癌质子重离子治疗-上海经验介绍(2019年8月17日)
2021年04月22日
会议视频
Independent cover meshless particle method for complex geotechnical engineering
Jianqiu WU, Yongchang CAI
期刊论文
Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer
期刊论文